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Tuesday, May 21, 2024

Canadian scientists develop a treatment that could cure ALS

Scientists from the Western University of London, in Ontario (Canada), could have found a cure for Amyotrophic Lateral Sclerosis (THE A). Led by Dr. Michael Strong, they could take this remedy to clinical trials in five years after three decades of work with patients and families.

In a study published in the journal Brain and which has also been echoed by her own Western UniversityStrong explains that the interactions between two proteins They could stop or reverse the death of nerve cells, one of the most distinctive symptoms of this disease.

Specifically, Strong’s team discovered that interacting these two proteins present in nerve cells affected by ALS can stop or reverse the progression of the pathology and what’s more, the team is already capable of making it possible.



Jaime Lafita, promoter of DalecandELA, with Gabia, his tandem partner in the challenge of traveling through Death Valley.

In almost all ALS patients, the protein called TDP-43 is responsible for forming abnormal groups inside cells, causing cell death. In recent years, Strong’s team has discovered the so-called RGNEF, with functions opposite to those of TDP-43. It is a specific fragment of the latter, NF242, that can mitigate the toxic effects of the pathology. When both proteins interact, this toxicity is eliminated.

“Importantly, this interaction could be key to unlocking a treatment not only for ALS, but also for other conditions related neurological disorders, such as frontotemporal dementia“Strong explained in his university magazine, where he also made it clear that this advance “is a turning point.”

Thanks to the donation of money from a philanthropist, Strong’s team has been able to carry out the research, which has already been tested in various animal species.

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